Regine Velasquez was the first Filipino to stage a solo concert at the Main Hall of Carnegie Hall, part of Carnegie Hall's centennial-year concert series. Her album Listen Without Prejudice achieved platinum certification in a few countries, although subsequent releases in Asia had not fared as well. In 20, she performed the country's millennial theme, televised in 55 broadcast networks throughout the world to coincide with midnight in Manila.
"In Love With You," a collaboration with Jacky Cheung, reached MTV Asia and Channel V music charts. She has collaborated with artists such as Paul Anka, David Hasselhoff, 98 Degrees, Brian McKnight, Mandy Moore, Ronan Keating, Stephen Bishop, Jim Brickman, Peabo Bryson, Jeffrey Osborne, Dave Koz , Lea Salonga, Grasshopper, Coco Lee, Michel Legrand and Billy Crawford.