Patrick Hughes is a young man at Univ. of Louisville who was born blind and crippled and yet now plays the piano beautifully as well as "marches" in the Louisville marching band. This was a piece done during ESPN College Gameday on 12/2/2006.
Note: I am not affiliated with the Hughes family. Just someone who finds their story wonderful.
Go to rickhenryhughes.com/ to find out more about Patrick.